Wholesale 99% Tauroursodeoxycholic Acid Powder CAS 14605-22-2
What is tauroursodeoxycholic acid(TUDCA?)
Tauroursodeoxycholic acid, commonly referred to as TUDCA, is a water-soluble (hydrophilic) bile acid found in large quantities in bear bile and is the primary component of synthetic bear bile. It is a conjugated bile acid widely found in the bile of humans and various animals and has multiple physiological and pharmacological effects. It exhibits significant hepatoprotective properties, including reducing oxidative stress, inhibiting apoptosis, and alleviating inflammation, thereby promoting liver cell repair and regeneration.
TEST REPORT
Mechanism of Action
Scientists propose that Tauroursodeoxycholic Acid may exert its effects through the following mechanisms:
Increasing glucose-induced insulin release and enhancing insulin sensitivity via the cAMP/PKA pathway.
Alleviating endoplasmic reticulum (ER) stress; the ER ensures the proper folding of proteins.
Reducing the programmed death (apoptosis) of healthy cells. TUDCA prevents the molecule BAX from reaching the mitochondria; BAX triggers the release of cytochrome c from the mitochondria, thereby initiating the activation of enzymes (caspases) that drive apoptosis.
Inactivating the Bcl-2-associated death promoter (BAD), a molecule involved in apoptosis.
Clearing toxic bile acids from the liver, thereby preventing them from damaging hepatocytes.
The Differences Between Tauroursodeoxycholic Acid and Ursodeoxycholic Acid
From a chemical structural perspective, tauroursodeoxycholic acid is a compound formed by the conjugation of ursodeoxycholic acid with taurine. This analogy likens ursodeoxycholic acid to a "rough diamond," while tauroursodeoxycholic acid represents a "finished piece of jewelry"—one that has undergone meticulous processing and setting. The structural differences between the two fundamentally determine their distinct subsequent functions.
In terms of mechanism of action, ursodeoxycholic acid primarily achieves the dissolution of cholesterol gallstones by inhibiting the intestinal reabsorption of cholesterol and reducing the saturation of cholesterol within the bile. Tauroursodeoxycholic acid not only retains some of the therapeutic properties of ursodeoxycholic acid but also excels in regulating bile acid metabolism and enhancing bile fluidity. It acts much like introducing additional "vitality factors" into the "river" of bile, thereby facilitating a smoother flow and mitigating the risk of bile stasis.
What are the benefits of tauroursodeoxycholic acid ?
Dissolving Cholesterol Gallstones
It increases the bile acid content in bile, reduces cholesterol saturation, and promotes the gradual dissolution of cholesterol gallstones.
Improving Cholestasis
It promotes bile secretion and excretion, reduces bile accumulation in the liver, and protects liver cells from damage caused by toxic bile acids. It is used to treat cholestatic liver diseases such as primary biliary cholangitis.
Cytoprotective Effects
It has anti-inflammatory, antioxidant, and anti-apoptotic effects, reducing cellular stress and damage, and has potential protective effects against neurodegenerative and cardiovascular diseases.
Pharmacological Effects
By promoting the secretion and flow of bile and increasing the concentration of bile salts within it, this mechanism reduces the deposition of cholesterol in the bile. This helps prevent the formation of gallstones and alleviates the symptoms of biliary tract diseases, such as cholecystitis and gallstones.
Research on Tauroursodeoxycholic Acid in Pets
1. Tauroursodeoxycholic acid can improve digestion and absorption in pets. Bile Acid Secretion: It stimulates the liver to synthesize primary bile acids in dogs and cats, enhancing the emulsification of dietary fat and improving intestinal absorption of lipids (including triglycerides and cholesterol) and fat-soluble vitamins (A/D/E/K). Pancreatic Lipase Activation: By regulating the intestinal alkaline environment, it significantly increases pancreatic lipase activity (canine studies have shown that lipolysis can increase by 12%-18%).
2. In terms of hepatobiliary protection, it reduces the accumulation of toxic bile acids (such as lithocholic acid) in canine and cat hepatocytes by downregulating the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, thereby alleviating cholestasis. Hepatocyte Repair: It inhibits hepatocyte apoptosis by activating the PI3K/Akt signaling pathway (clinical data show that after four weeks of treatment, ALT levels in cats with fatty liver decreased by an average of 43%).
3. Improve intestinal function and anti-inflammatory effects: Targeting the farnesoid X receptor (FXR), inhibiting the nuclear factor kappa B (NF-κB) pathway, and reducing the release of intestinal pro-inflammatory factors IL-6 and TNF-α. Mucosal barrier repair: Increasing the expression of tight junction proteins (ZO-1, occludin) and reducing the increased intestinal mucosal permeability caused by oxidative stress.
FAQ
Q: Do your products pass third-party testing?
A: All raw materials are tested by internal laboratory and authoritative third-party institutions. Heavy metals, residual solvents, microbial limits and pesticide residues are strictly controlled.
Q: Are your raw materials GMP / HALAL / KOSHER certified?
A: Our production bases follow GMP manufacturing standards. Most products have HALAL, KOSHER, ISO22000 and HACCP certificates. Relevant certification files can be provided upon request.
Q: What is your standard packaging?
A: Standard package: 25kg/drum (food-grade cardboard drum with inner PE bag). Small trial packages (1kg, 10kg) are also available.
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